Invention Grant
US08143027B2 Method of making a plasminogen activator polypeptide with clot-specific streptokinase activity
有权
制备具有凝块特异性链激酶活性的纤溶酶原激活物多肽的方法
- Patent Title: Method of making a plasminogen activator polypeptide with clot-specific streptokinase activity
- Patent Title (中): 制备具有凝块特异性链激酶活性的纤溶酶原激活物多肽的方法
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Application No.: US11781927Application Date: 2007-07-23
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Publication No.: US08143027B2Publication Date: 2012-03-27
- Inventor: Girish Sahni , Rajesh Kumar , Chiati Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
- Applicant: Girish Sahni , Rajesh Kumar , Chiati Roy , Kammara Rajagopal , Deepak Nihalani , Vasudha Sundaram , Mahavir Yadav
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific & Industrial Research of Rafi Marg
- Current Assignee: Council of Scientific & Industrial Research of Rafi Marg
- Current Assignee Address: IN New Delhi
- Agency: Sughrue Mion, PLLC
- Priority: IN3825/DEL/98 19981224
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C07K1/00
Abstract:
The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
Public/Granted literature
- US20080171362A1 Polynucleotides Encoding Proteins with Clot-Specific Streptokinase Activity Public/Granted day:2008-07-17
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