发明授权
- 专利标题： Trisubstituted 1,2,4-triazoles
- 专利标题（中）： 三取代的1,2,4-三唑
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申请号： US12297059申请日： 2007-04-19
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公开(公告)号： US08143419B2公开(公告)日： 2012-03-27
- 发明人: Johannes Wilhelmus John F. Thuring , Gregor James MacDonald , Anne Simone Josephine Lesage , Wei Zhuang , Marcel Frans Leopold De Bruyn , Frans Alfons Maria Van Den Keybus , Yves Emiel Maria Van Roosbroeck , Theodorus Dinklo , James Edward Stewart Duffy
- 申请人： Johannes Wilhelmus John F. Thuring , Gregor James MacDonald , Anne Simone Josephine Lesage , Wei Zhuang , Marcel Frans Leopold De Bruyn , Frans Alfons Maria Van Den Keybus , Yves Emiel Maria Van Roosbroeck , Theodorus Dinklo , James Edward Stewart Duffy
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N. V.
- 当前专利权人： Janssen Pharmaceutica N. V.
- 当前专利权人地址： BE Beerse
- 代理商 Andrea Jo Kamage
- 优先权： EP06112754 20060419
- 国际申请： PCT/EP2007/053829 WO 20070419
- 国际公布： WO2007/118903 WO 20071025
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; C07D249/08
摘要：
The present invention relates to 3-aniline-5-aryl triazole derivatives and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formula (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.
公开/授权文献
- US20090253691A1 TRISUBSTITUTED 1,2,4-TRIAZOLES 公开/授权日：2009-10-08