Deduplication of data using a low-latency random read memory (LLRRM) is described herein. Upon receiving a block, if a matching block stored on a disk device is found, the received block is deduplicated by producing an index to the address location of the matching block. In some embodiments, a matching block having a predetermined threshold number of associated indexes that reference the matching block is transferred to LLRRM, the threshold number being one or greater. Associated indexes may be modified to reflect the new address location in LLRRM. Deduplication may be performed using a mapping mechanism containing mappings of deduplicated blocks to matching blocks, the mappings being used for performing read requests. Deduplication described herein may reduce read latency as LLRRM has relatively low latency in performing random read requests relative to disk devices.