In one aspect, the invention provides a female stimulation system that includes a device body having an operating region and a body contacting surface, and means for controlling a vacuum produced by the device body when the device body is applied to a user. In addition, the female stimulation system includes an applicator adapted to apply a biocompatible substance to the body contacting surface. In one or more embodiments, the applicator may be a pad, form-fitted insert, or a capsule.