发明授权
- 专利标题： Bioconjugates as therapeutic agent and synthesis thereof
- 专利标题（中）： 生物共轭物作为治疗剂及其合成
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申请号： US12234233申请日： 2008-09-19
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公开(公告)号： US08148321B2公开(公告)日： 2012-04-03
- 发明人: Rajendra Prasad Roy , Sharmishtha Samantaray
- 申请人： Rajendra Prasad Roy , Sharmishtha Samantaray
- 申请人地址： US IN New Dehli
- 专利权人： National Institute of Immunology
- 当前专利权人： National Institute of Immunology
- 当前专利权人地址： US IN New Dehli
- 代理机构： Reinhart Boerner Van Deuren P.C.
- 优先权： IN797/DEL/2006 20060322
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K31/70 ; A01N43/04
摘要：
The present disclosure relates to a novel enzymatic approach according to the invention using an unprecedented sortase-catalyzed transpeptidation reaction between a substrate comprising LPXTG (SEQ ID NO: 11) peptide motif and biomolecules such as aminosugars, hydroxyamino acids, hydroxyamino acid esters, aminolipids, polyamines; nucleic acids or derivatives thereof; or any molecule having such moieties; or any compound having such moieties to obtain a bioconjugates useful for target delivery of a compound. The present disclosure provides bioconjugates obtained by the novel sortase catalysed transpeptidedation reaction.
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