发明授权
US08148324B2 Chemoenzymatic methods for the synthesis of statins and statin intermediates
有权
用于合成他汀类药物和他汀类药物中间体的化疗酶法
- 专利标题: Chemoenzymatic methods for the synthesis of statins and statin intermediates
- 专利标题(中): 用于合成他汀类药物和他汀类药物中间体的化疗酶法
-
申请号: US12032337申请日: 2008-02-15
-
公开(公告)号: US08148324B2公开(公告)日: 2012-04-03
- 发明人: William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
- 申请人: William Greenberg , Mark J. Burk , Alexander Varvak , Kelvin Wong
- 申请人地址: US CA San Diego
- 专利权人: Verenium Corporation
- 当前专利权人: Verenium Corporation
- 当前专利权人地址: US CA San Diego
- 代理机构: Verenium Corporation
- 代理商 Brian W. Siddons; Lynn M. Linkowski
- 主分类号: C07K14/00
- IPC分类号: C07K14/00 ; C12P21/00
摘要:
The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
公开/授权文献
信息查询