发明授权
US08148324B2 Chemoenzymatic methods for the synthesis of statins and statin intermediates 有权
用于合成他汀类药物和他汀类药物中间体的化疗酶法

Chemoenzymatic methods for the synthesis of statins and statin intermediates
摘要:
The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
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