Invention Grant
US08148378B2 Pyridazine derivatives and their use as inhibitors of stearoyl-CoA desaturase-1 activity in a mammal
失效
哒嗪衍生物及其作为哺乳动物硬脂酰辅酶A去饱和酶-1活性抑制剂的用途
- Patent Title: Pyridazine derivatives and their use as inhibitors of stearoyl-CoA desaturase-1 activity in a mammal
- Patent Title (中): 哒嗪衍生物及其作为哺乳动物硬脂酰辅酶A去饱和酶-1活性抑制剂的用途
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Application No.: US12390117Application Date: 2009-02-20
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Publication No.: US08148378B2Publication Date: 2012-04-03
- Inventor: Heinz W. Gschwend , Vishnumurthy Kodumuru , Shifeng Liu , Rajender Kamboj
- Applicant: Heinz W. Gschwend , Vishnumurthy Kodumuru , Shifeng Liu , Rajender Kamboj
- Applicant Address: CA Burnaby, BC
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby, BC
- Agency: Seed IP Law Group PLLC
- Main IPC: A61K31/501
- IPC: A61K31/501 ; A61P3/06 ; A61P9/00 ; A61P3/10 ; A61P3/04 ; A61P3/00
Abstract:
A method of treating an SCD-mediated disease or condition in a mammal, preferably a human, includes administering to a mammal a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. The SCD-mediated disease or condition may be selected from the group consisting of Type II diabetes, impaired glucose tolerance, insulin resistance, obesity, fatty liver, non-alcoholic steatohepatitis, dyslipidemia, metabolic syndrome, acne, cardiovascular disease, hypertriglyceridemia, inflammation, cancer, and any combination of these.
Public/Granted literature
- US20090197890A1 PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS Public/Granted day:2009-08-06
Information query
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