Invention Grant
US08148391B2 Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
有权
2,4-二氨基嘧啶作为ALK和c-Met抑制剂的稠合双环衍生物
- Patent Title: Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors
- Patent Title (中): 2,4-二氨基嘧啶作为ALK和c-Met抑制剂的稠合双环衍生物
-
Application No.: US12162851Application Date: 2007-10-23
-
Publication No.: US08148391B2Publication Date: 2012-04-03
- Inventor: Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
- Applicant: Gulzar Ahmed , Henry Joseph Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph G. Lisko , Rong-Qiang Liu , Eugen Florin Mesaros , Karen Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho V. Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
- Applicant Address: US PA Frazer
- Assignee: Cephalon, Inc.
- Current Assignee: Cephalon, Inc.
- Current Assignee Address: US PA Frazer
- International Application: PCT/US2007/022496 WO 20071023
- International Announcement: WO2008/051547 WO 20080502
- Main IPC: A61K31/505
- IPC: A61K31/505 ; C07D239/02
Abstract:
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
Public/Granted literature
- US20090221555A1 FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS Public/Granted day:2009-09-03
Information query
