A multi-protocol communication circuit, for example, a serializer-deserializer (SerDes) circuit for communicating between an internal logic circuit and an external link includes a select terminal configured to accept a select signal representing a plurality of mode select signal. A SerDes core is coupled to the select terminal and configured to transmit outbound data conforming with a first communication protocol in response to a first mode select signal and conforming with a second communication protocol in response to a second mode select signal. The SerDes core is also configured to receive inbound data respective to a first communication protocol in response to a first mode select signal and respective to a second communication protocol in response to a second mode select signal. Advantages of the invention include the ability to provide high bandwidth communications between integrated circuits that employ different SerDes protocols.