This disclosure relates to a secure network device for multi-homed devices. An example network device includes a state table, an association establishment module, and an inspection module. The state table is configured to store information for communication associations between devices. The association establishment module is configured to process a request to establish a communication association between a first device and a second device and to store state information for the communication association in the state table. The first device and the second device each comprise a multi-homed device associated with a plurality of Internet Protocol (IP) addresses, and the state information includes the IP addresses associated with the first device and the IP addresses associated with the second device. The inspection module is configured to secure the communication association between the first device and the second device by using the state information that is stored in the state table.