Invention Grant
US08153154B2 Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery systems
有权
用于基因递送系统的精氨酸缀合的生物还原性聚（二硫化物胺）聚合物
- Patent Title: Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery systems
- Patent Title (中): 用于基因递送系统的精氨酸缀合的生物还原性聚（二硫化物胺）聚合物
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Application No.: US12370515Application Date: 2009-02-12
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Publication No.: US08153154B2Publication Date: 2012-04-10
- Inventor: Sung Wan Kim , Tae-il Kim
- Applicant: Sung Wan Kim , Tae-il Kim
- Applicant Address: US UT Salt Lake City
- Assignee: University of Utah
- Current Assignee: University of Utah
- Current Assignee Address: US UT Salt Lake City
- Agency: Clayton, Howarth & Cannon, P.C.
- Main IPC: A61K9/14
- IPC: A61K9/14 ; C07H21/04
Abstract:
An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity.
Public/Granted literature
- US20090233365A1 ARGININE-CONJUGATED BIOREDUCIBLE POLY(DISULFIDE AMINE) POLYMERS FOR GENE DELIVERY SYSTEMS Public/Granted day:2009-09-17
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