发明授权
- 专利标题： Process for making 3-substituted 2-amino-5-halobenzamides
- 专利标题（中）： 制备3-取代的2-氨基-5-卤代苯甲酰胺的方法
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申请号： US12373651申请日： 2007-06-27
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公开(公告)号： US08153844B2公开(公告)日： 2012-04-10
- 发明人: Richard F. Davis , Rafael Shapiro , Eric G. Taylor
- 申请人： Richard F. Davis , Rafael Shapiro , Eric G. Taylor
- 申请人地址： US DE Wilmington
- 专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 代理商 Roman Kucharczyk
- 国际申请： PCT/US2007/014972 WO 20070627
- 国际公布： WO2008/010897 WO 20080124
- 主分类号： C07C231/02
- IPC分类号： C07C231/02 ; C07C271/28 ; C07D265/26
摘要：
Disclosed is a method for preparing a compound of Formula 1 by contacting compound of Formula 2 with R1—NH2 in the presence of a carboxylic acid and a method for preparing a compound of Formula 2 by contacting a compound of Formula 4 with phosphorus tribromide. wherein R1 is H, C1-C4 alkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl; R2 is CH3 or Cl; R3 is C1-C6 alkyl or C3-C6 alkenyl, each optionally substituted with up to 3 halogen and up to 1 phenyl; and X is Cl or Br. Also disclosed is a method for preparing a compound of Formula 5 wherein R4, R5, R6 and Z are as defined in the disclosure, using a compound of Formula 1 that is characterized by preparing the compound of Formula 1 by the method above.