Invention Grant
- Patent Title: Heterocycles substituted pyridine derivatives and antifungal agent containing thereof
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Application No.: US12704637Application Date: 2010-02-12
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Publication No.: US08158657B2Publication Date: 2012-04-17
- Inventor: Keigo Tanaka , Satoshi Inoue , Norio Murai , Masayuki Matsukura , Kazutaka Nakamoto , Shuji Shirotori , Shinya Abe
- Applicant: Keigo Tanaka , Satoshi Inoue , Norio Murai , Masayuki Matsukura , Kazutaka Nakamoto , Shuji Shirotori , Shinya Abe
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2005-317680 20051031; JP2005-374395 20051227
- Main IPC: A61K31/443
- IPC: A61K31/443 ; C07D413/04

Abstract:
An object of the present invention is to provide an antifungal agent which has excellent antifungal effects and is superior in terms of its physical properties, safety and metabolic stability. According to the present invention, there is disclosed a compound represented by the following formula (I), or a salt thereof: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxy C1-6 alkyl group; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group or a di C1-6 alkylamino group; one of X and Y is a nitrogen atom while the other is a nitrogen atom or an oxygen atom; ring A represents a 5- or 6-member heteroaryl ring or a benzene ring which may have a halogen atom, or 1 or 2 C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom, a sulfur atom, —CH2O—, —OCH2—, —NH—, —CH2NH—, —NHCH2—, —CH2S—, or —SCH2—; R3 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-member heteroaryl group, or 5- or 6-member non-aromatic heterocyclic group which may have 1 or 2 substituents; and R4 represents a hydrogen atom or a halogen atom.
Public/Granted literature
- US20100168173A1 HETEROCYCLES SUBSTITUTED PYRIDINE DERIVATIVES AND ANTIFUNGAL AGENT CONTAINING THEREOF Public/Granted day:2010-07-01
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