Invention Grant
US08158671B2 Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
有权
吲哚和二氢吲哚环丙基酰胺衍生物作为EP4受体拮抗剂
- Patent Title: Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
- Patent Title (中): 吲哚和二氢吲哚环丙基酰胺衍生物作为EP4受体拮抗剂
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Application No.: US12527736Application Date: 2008-02-22
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Publication No.: US08158671B2Publication Date: 2012-04-17
- Inventor: Michael Boyd , John Colucci , Yongxin Han
- Applicant: Michael Boyd , John Colucci , Yongxin Han
- Applicant Address: CA Kirkland, Quebec
- Assignee: Merck Canada Inc.
- Current Assignee: Merck Canada Inc.
- Current Assignee Address: CA Kirkland, Quebec
- Agent Maria V. Marucci; Valerie J. Camara
- International Application: PCT/CA2008/000351 WO 20080222
- International Announcement: WO2008/104055 WO 20080904
- Main IPC: A61K31/404
- IPC: A61K31/404 ; A61K31/437 ; C07D209/08 ; C07D487/04
Abstract:
The invention is directed to indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. Pharmaceutical compositions and methods of use are also included.
Public/Granted literature
- US20090318518A1 INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS Public/Granted day:2009-12-24
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