发明授权
- 专利标题: Six-membered heterocycles useful as serine protease inhibitors
- 专利标题(中): 用作丝氨酸蛋白酶抑制剂的六元杂环
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申请号: US12097080申请日: 2006-12-13
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公开(公告)号: US08163749B2公开(公告)日: 2012-04-24
- 发明人: James R. Corte
- 申请人: James R. Corte
- 申请人地址: US NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: US NJ Princeton
- 代理商 Hong Liu
- 国际申请: PCT/US2006/061973 WO 20061213
- 国际公布: WO2007/070818 WO 20070621
- 主分类号: A01N43/58
- IPC分类号: A01N43/58 ; A61K31/50 ; A61K31/44 ; A61K31/13 ; C07D221/18 ; C07D421/00
摘要:
The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, R3 and R11 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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