Invention Grant
US08163907B2 Dihydropyridine calcium antagonist compounds, preparation methods, and medical uses thereof
有权
二氢吡啶类钙拮抗剂化合物,其制备方法及其医疗用途
- Patent Title: Dihydropyridine calcium antagonist compounds, preparation methods, and medical uses thereof
- Patent Title (中): 二氢吡啶类钙拮抗剂化合物,其制备方法及其医疗用途
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Application No.: US12863593Application Date: 2009-01-05
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Publication No.: US08163907B2Publication Date: 2012-04-24
- Inventor: Guo-hua Chen , Li Wang
- Applicant: Guo-hua Chen , Li Wang
- Applicant Address: CN Fujian
- Assignee: Cosunter Pharmaceutical Company
- Current Assignee: Cosunter Pharmaceutical Company
- Current Assignee Address: CN Fujian
- Priority: CN200810018711 20080121
- International Application: PCT/CN2009/070031 WO 20090105
- International Announcement: WO2009/092301 WO 20090730
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D213/80

Abstract:
A dihydropyridine (DHP) calcium antagonist compound and its preparation method and medical use are related to preparation methods of compounds of general formulas (I) and (II) as shown below and their pharmaceutical salts and applications for treating cardiovascular diseases, and R1 represents a substituted or unsubstituted heterocyclic, aromatic ring or aralkyl group, and the substituent may be C1-C4 alkyl, C1-C4 alkoxyl, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro, amino or hydroxyl group; R2 represents a C1-C8 alkyl group; R3 and R4 are the same or different, and each represents a hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro or amino group or a C1-C4 alkyl, C1-C4 alkoxyl, C1-C4 alkenyl, or C1-C4 alkinyl group; R5 and R6 are the same or different, and each represents a C1-C4 alkyl group; X represents O, S or a single bond; m=0-6, n=1-6, and m and n are the same or different.
Public/Granted literature
- US20110201811A1 DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS, AND MEDICAL USES THEREOF Public/Granted day:2011-08-18
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