The present invention is adapted for field of electronic circuit protection and provides a security protection box, for enclosing the protected region of a protected circuit board in order to protect the elements in the protected region. The security protection box comprises a circuit board. The circuit board with thin center and thick periphery forms a box shape, and has the circuit routing layers. The circuit routing layers trigger the associated circuit to erase or destroy the information in the elements in the protected region when the circuit routing layers are physically attacked. The present invention protects the elements in the protected region through covering the protected region on the protected circuit board with a circuit board having thin center and thick periphery.