A method and apparatus are provided for effectively predicting a video frame that use all of the advantages of an intra mode and an intra BL mode in multi-layer structure based-video coding. The method includes reconstructing the intra block of a lower layer using the previously reconstructed first neighboring blocks of the intra block; subtracting the first neighboring blocks from previously stored the second neighboring blocks of an upper layer corresponding to the first neighboring blocks; creating a differential predicted block based on a predetermined intra prediction mode by performing intra prediction using virtual differential neighboring blocks that are created as a result of the subtraction; adding the differential predicted block and the reconstructed intra block; and subtracting a predicted block, which is created as a result of the addition, from a block of the upper layer corresponding to the intra block.