发明授权
US08168194B2 Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
有权
包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和人免疫缺陷病毒（HIV）Tat支架多肽的融合蛋白
- 专利标题： Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
- 专利标题（中）： 包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和人免疫缺陷病毒（HIV）Tat支架多肽的融合蛋白
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申请号： US11883696申请日： 2006-02-03
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公开(公告)号： US08168194B2公开(公告)日： 2012-05-01
- 发明人: Susan Barnett , Rino Rappuoli , Victoria A. Sharma , Indresh K. Srivastava , Jan Zur Megede
- 申请人： Susan Barnett , Rino Rappuoli , Victoria A. Sharma , Indresh K. Srivastava , Jan Zur Megede
- 申请人地址： US CA Emeryville
- 专利权人： Novartis Vaccines & Diagnostics, Inc.
- 当前专利权人： Novartis Vaccines & Diagnostics, Inc.
- 当前专利权人地址： US CA Emeryville
- 代理商 Regina Bautista; Helen Lee
- 国际申请： PCT/US2006/003935 WO 20060203
- 国际公布： WO2006/084179 WO 20060810
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/21 ; A61K38/00 ; C07K1/00
摘要：
Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
公开/授权文献
- US20080317779A1 Hiv Tat-Cd4 Hybrid Molecules and Methods of Use Thereof 公开/授权日：2008-12-25
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