Invention Grant
- Patent Title: Pharmaceutical composition comprising an extract of Pseudolysimachion longifolium and the catalpol derivatives isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity
- Patent Title (中): 药物组合物，其包含假单胞菌属植物提取物和从其分离的梓醇衍生物，其具有抗炎，抗过敏和抗哮喘活性
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Application No.: US11916216Application Date: 2006-05-30
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Publication No.: US08168235B2Publication Date: 2012-05-01
- Inventor: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
- Applicant: Hyeong Kyu Lee , Sei Ryang Oh , Kyung Seop Ahn , Sang Ku Lee , Joong Ku Lee , Ok Kyoung Kwon , Doo Young Kim , Hyouk Joung , Gui Hua Quan , Mi Jin Kim , Bo Young Park
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Lucas & Mercanti, LLP
- Priority: KR10-2005-0045755 20050530; KR10-2005-0045756 20050530; KR10-2006-0048104 20060529; KR10-2006-0048319 20060529
- International Application: PCT/KR2006/002092 WO 20060530
- International Announcement: WO2006/129964 WO 20061207
- Main IPC: A61K36/00
- IPC: A61K36/00
Abstract:
The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
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