Invention Grant
US08168639B2 Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof 有权
异三环化合物作为血清素能和/或多巴胺能药物及其用途

  • Patent Title: Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
  • Patent Title (中): 异三环化合物作为血清素能和/或多巴胺能药物及其用途
  • Application No.: US12532869
    Application Date: 2007-09-24
  • Publication No.: US08168639B2
    Publication Date: 2012-05-01
  • Inventor: Vladimir Kogan
  • Applicant: Vladimir Kogan
  • Applicant Address: LU Luxembourg
  • Assignee: ATIR Holding S.A.
  • Current Assignee: ATIR Holding S.A.
  • Current Assignee Address: LU Luxembourg
  • Priority: WOPCT/IL2007/000404 20070328
  • International Application: PCT/IL2007/001174 WO 20070924
  • International Announcement: WO2008/117269 WO 20081002
  • Main IPC: A61K31/497
  • IPC: A61K31/497 A61K31/505 C07D401/00 C07D239/00 A01N43/54
Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
Abstract:
Novel heterocyclic compounds of formula I: A-B-D  Formula I or a pharmaceutically acceptable salt thereof, wherein: A is selected from the group consisting of a moiety having general Formula II and a moiety having general Formula III: B is a moiety selected from the group consisting of: D is a moiety selected from the group consisting of:  which exhibit a dopamine receptor (preferably a D4 receptor) and/or a serotonine receptor (preferably 5HTA1 agonistic activity), processes of preparing same, pharmaceutical compositions containing same and uses thereof in the treatment of medical conditions associated with the dopaminergic and/or serotonergic systems (e.g., sexual disorders, dyskinesia, anxiety) are disclosed.
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