发明授权
- 专利标题： Aspartyl protease inhibitors
- 专利标题（中）： 天冬氨酰蛋白酶抑制剂
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申请号： US11759336申请日： 2007-06-07
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公开(公告)号： US08168641B2公开(公告)日： 2012-05-01
- 发明人: Yusheng Wu , Ulrich Iserloh , Jared N. Cumming , Xiaoxiang Liu , Robert D. Mazzola , Zhong-Yue Sun , Ying Huang , Andrew Stamford , Brian McKittrick , Zhaoning Zhu
- 申请人： Yusheng Wu , Ulrich Iserloh , Jared N. Cumming , Xiaoxiang Liu , Robert D. Mazzola , Zhong-Yue Sun , Ying Huang , Andrew Stamford , Brian McKittrick , Zhaoning Zhu
- 申请人地址： US NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： US NJ Kenilworth
- 代理商 Keith D. MacMillan; Gerard M. Devlin
- 主分类号： C07D239/20
- IPC分类号： C07D239/20 ; C07D239/22 ; A61K31/497 ; A61K31/513 ; A61K31/506 ; A61P9/00 ; A61P25/28 ; A61P31/18 ; C07D495/20 ; A61K31/527
摘要：
Disclosed are compounds of formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
公开/授权文献
- US20070287692A1 ASPARTYL PROTEASE INHIBITORS 公开/授权日：2007-12-13