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US08168772B2 Nucleic acids encoding novel chimeric C15/prM/E dengue virus immunogens prepared by DNA shuffling 有权
编码通过DNA改组制备的新型嵌合C15 / prM / E登革热病毒免疫原的核酸

Nucleic acids encoding novel chimeric C15/prM/E dengue virus immunogens prepared by DNA shuffling
Abstract:
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability to induce an immune response to flaviviruses. The polypeptides and polynucleotides of the invention are useful in methods of inducing immune response against flaviviruses, including dengue viruses. Compositions and methods for utilizing polynucleotides and polypeptides of the invention are also provided.
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