发明授权
US08173814B2 Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
有权
（E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式
![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/docs/US/2012-05-08/US08173814B2/abs.jpg.600x600.jpg)
- 专利标题： Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
- 专利标题（中）： （E）-N- {4- [3-氯-4-（2-吡啶基甲氧基）苯胺基] -3-氰基-7-乙氧基-6-喹啉基} -4-（二甲基氨基）-2-丁烯酰胺的马来酸盐和 其结晶形式
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申请号： US13181375申请日： 2011-07-12
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公开(公告)号： US08173814B2公开(公告)日： 2012-05-08
- 发明人: Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
- 申请人： Qinghong Lu , Mannching Sherry Ku , Warren Chew , Gloria Cheal , Anthony F. Hadfield , Mahmoud Mirmehrabi
- 申请人地址： US NJ Madison
- 专利权人： Wyeth LLC
- 当前专利权人： Wyeth LLC
- 当前专利权人地址： US NJ Madison
- 代理机构： Jones Day
- 主分类号： C07D215/44
- IPC分类号： C07D215/44
![Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof](/abs-image/US/2012/05/08/US08173814B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
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