发明授权
US08178101B2 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
有权
使用具有特异性结合特性的抗IL-6抗体治疗恶病质
- 专利标题: Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
- 专利标题(中): 使用具有特异性结合特性的抗IL-6抗体治疗恶病质
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申请号: US12391717申请日: 2009-02-24
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公开(公告)号: US08178101B2公开(公告)日: 2012-05-15
- 发明人: Leon Garcia-Martinez , Anne Elisabeth Carvalho Jensen , Katie Olson , Ben Dutzar , Ethan Ojala , Brian Kovacevich , John Latham , Jeffrey T. L. Smith
- 申请人: Leon Garcia-Martinez , Anne Elisabeth Carvalho Jensen , Katie Olson , Ben Dutzar , Ethan Ojala , Brian Kovacevich , John Latham , Jeffrey T. L. Smith
- 申请人地址: US NV Las Vegas
- 专利权人: Alderbio Holdings Inc.
- 当前专利权人: Alderbio Holdings Inc.
- 当前专利权人地址: US NV Las Vegas
- 代理机构: Hunton & Williams LLP
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C12P21/08 ; C07K16/24
摘要:
The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.
公开/授权文献
- US20090297513A1 ANTIBODIES TO IL-6 AND USE THEREOF 公开/授权日:2009-12-03
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