发明授权
US08178294B2 Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
有权
用于确定发展胰岛素抵抗，冠状动脉疾病和其他表型的风险的基于单倍型的遗传分析方法
- 专利标题： Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
- 专利标题（中）： 用于确定发展胰岛素抵抗，冠状动脉疾病和其他表型的风险的基于单倍型的遗传分析方法
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申请号： US11564243申请日： 2006-11-28
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公开(公告)号： US08178294B2公开(公告)日： 2012-05-15
- 发明人: Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
- 申请人： Kent D. Taylor , Jerome I. Rotter , Huiying Yang , Willa A. Hsueh , Xiuqing Guo , Leslie J. Raffel , Mark O. Goodarzi , Yii-Der Ida Chen
- 申请人地址： US CA Los Angeles
- 专利权人： Cedars-Sinai Medical Center
- 当前专利权人： Cedars-Sinai Medical Center
- 当前专利权人地址： US CA Los Angeles
- 代理机构： Davis Wright Tremaine LLP
- 代理商 Sean D. Senn
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34
摘要：
Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary artery disease. Thus, also disclosed are a method of detecting a genetic predisposition in a human subject for certain biological conditions, which may be related to coronary artery disease.
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