Invention Grant
- Patent Title: Methods for increasing thermogenic adipocytes
- Patent Title (中): 增加产热脂肪细胞的方法
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Application No.: US12796332Application Date: 2010-06-08
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Publication No.: US08178488B2Publication Date: 2012-05-15
- Inventor: John Knopf , Jasbir Seehra , Ravindra Kumar
- Applicant: John Knopf , Jasbir Seehra , Ravindra Kumar
- Applicant Address: US MA Cambridge
- Assignee: Acceleron Pharma, Inc.
- Current Assignee: Acceleron Pharma, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Ropes & Gray LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K16/46
Abstract:
In certain aspects, the present invention provides compositions and methods for increasing thermogenic adipocytes (e.g., brown adipocytes or other UCP-1 expressing adipocytes) by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, anti-Nodal, anti-activin, and anti-GDF11 antibodies. A variety of metabolic and other disorders may be treated by causing an increase in thermogenic adipocytes.
Public/Granted literature
- US20100310577A1 METHODS FOR INCREASING THERMOGENIC ADIPOCYTES Public/Granted day:2010-12-09
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