Invention Grant
US08178525B2 FXA inhibitors with cyclic amidoxime or cyclic amidrazone as P4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
有权
具有环偕胺肟或环状氨基腙作为P4亚基的FXA抑制剂，其制备方法及其药物组合物及其衍生物
- Patent Title: FXA inhibitors with cyclic amidoxime or cyclic amidrazone as P4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
- Patent Title (中): 具有环偕胺肟或环状氨基腙作为P4亚基的FXA抑制剂，其制备方法及其药物组合物及其衍生物
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Application No.: US13002271Application Date: 2009-06-05
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Publication No.: US08178525B2Publication Date: 2012-05-15
- Inventor: Ho Young Song , Young Lag Cho , Dae Yon Lee , Hee Sock Park , Sung Yoon Baek , Sang Eun Chae , Sang Hui Jo , Yeon Ok Kim , Hyang Sook Lee , Ju Hyun Park , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
- Applicant: Ho Young Song , Young Lag Cho , Dae Yon Lee , Hee Sock Park , Sung Yoon Baek , Sang Eun Chae , Sang Hui Jo , Yeon Ok Kim , Hyang Sook Lee , Ju Hyun Park , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
- Applicant Address: KR Daejeon
- Assignee: Legochem Bioscience Ltd.
- Current Assignee: Legochem Bioscience Ltd.
- Current Assignee Address: KR Daejeon
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2008-0064178 20080703
- International Application: PCT/KR2009/003008 WO 20090605
- International Announcement: WO2010/002115 WO 20100107
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D413/14 ; C07D487/04 ; A61K31/5395 ; A61K31/53
Abstract:
Disclosed are novel oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group, pharmaceutically acceptable salts thereof, methods for preparing the same and pharmaceutical compositions containing the same. The oxazolidinone derivatives with cyclic amidoxime or cyclic amidrazone group or the pharmaceutically acceptable salts thereof can be effectively used for the treatment of thromboembolism and tumor as an anticoagulant based on the inhibition of factor Xa.
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