Invention Grant
- Patent Title: Tie-2 modulators and methods of use
- Patent Title (中): Tie-2调制剂和使用方法
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Application No.: US10552424Application Date: 2004-04-08
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Publication No.: US08178570B2Publication Date: 2012-05-15
- Inventor: Jeff Chen , Lisa Esther Dalrymple , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , James William Leahy , Brian Hugh Ridgway , Grace Mann , Larry W. Mann , Craig Stacy Takeuchi , Joan C. Sangalang
- Applicant: Jeff Chen , Lisa Esther Dalrymple , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , James William Leahy , Brian Hugh Ridgway , Grace Mann , Larry W. Mann , Craig Stacy Takeuchi , Joan C. Sangalang
- Applicant Address: US CA South San Francisco
- Assignee: Exelixis, Inc.
- Current Assignee: Exelixis, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- International Application: PCT/US2004/010626 WO 20040408
- International Announcement: WO2004/091480 WO 20041028
- Main IPC: A01N43/64
- IPC: A01N43/64 ; A01N43/54 ; A61K31/41 ; C07D239/42 ; C07D401/04 ; C07D249/08
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Public/Granted literature
- US20060293342A1 Tie-2 modulators and methods of use Public/Granted day:2006-12-28
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