A power subsystem is actively optimized to improve total subsystem efficiency in a way that is responsive to changes in load requirements, power supply variations, and subsystem temperature variations. Detailed, multidimensional power loss models are developed for constituent devices which are then combined into a power subsystem containing a controller and circuity for measuring device operating parameters such as input and output voltage, output current, and temperature. Operating parameters are continually monitored, and set points are correspondingly changed based on the detailed power loss models to achieve maximum overall efficiency for the instantaneous operating state of the system.