A system for driving a hardware device and processing data and a method thereof are provided. The system includes a storage unit, a processor, and the hardware device. The storage unit stores a multimedia application interface, a virtual window driving model (WDM) interface, and a multimedia application. The processor is electrically connected with the storage unit and used for executing a multimedia application. The hardware device receives or outputs first format data. When the multimedia application and the hardware device are active, the multimedia application interface and the virtual WDM interface are taken as communication interfaces between the multimedia application and the hardware device, and the virtual WDM interface converts the first format data to second format data and transmits the second format data to the multimedia application via the multimedia application interface, and the second format data is processed by the multimedia application.