发明授权
US08183264B2 Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
有权
被杂芳基环取代的吡啶衍生物,及含有它们的抗真菌剂
- 专利标题: Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
- 专利标题(中): 被杂芳基环取代的吡啶衍生物,及含有它们的抗真菌剂
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申请号: US12442293申请日: 2007-09-20
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公开(公告)号: US08183264B2公开(公告)日: 2012-05-22
- 发明人: Masayuki Matsukura , Satoshi Inoue , Keigo Tanaka , Norio Murai , Shuji Shirotori
- 申请人: Masayuki Matsukura , Satoshi Inoue , Keigo Tanaka , Norio Murai , Shuji Shirotori
- 申请人地址: JP Tokyo
- 专利权人: Eisai R&D Managment Co., Ltd.
- 当前专利权人: Eisai R&D Managment Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: JP2006-256094 20060921
- 国际申请: PCT/JP2007/068230 WO 20070920
- 国际公布: WO2008/035726 WO 20080327
- 主分类号: A61K31/4439
- IPC分类号: A61K31/4439 ; C07D401/04
摘要:
The present invention provides an antifungal agent that has excellent antifungal action, and is also excellent in terms of its properties, safety, and metabolic stability. The present invention discloses a compound represented by the following formula I or a salt thereof, and an antifungal agent comprising the compound or the salt: wherein R1 represents a hydrogen atom, a halogen atom, an amino group, a C1-6 alkyl group, a C1-6 alkoxy group, or a C1-6-alkoxy-C1-6-alkyl group; R2 represents a hydrogen atom or an amino group; X, Y, Z, and W independently represent a nitrogen atom, an oxygen atom, a sulfur atom, or —CH—, provided that at least two among X, Y, and W are nitrogen atoms; the ring A represents a 5- or 6-membered heteroaryl ring or a benzene ring; Q represents a methylene group, an oxygen atom, —CH2O—, —OCH2—, —NH—, —NHCH2—, or —CH2NH—; and R3 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, or a 5- or 6-membered heteroaryl group, each of which may have one or two substituents.
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