In a disclosed imaging method, the instantaneous speed or data acquisition dwell times of a detector head (14, 16) is optimized as a function of position along a path (P) of the detector head around a subject (S, SS, SXL). The optimization is respective to an expected radioactive emission profile (EPROI) of a region of interest (H, HS, HXL) that is less than the entire subject. The detector head is traversed along the path using the optimized instantaneous speed or data acquisition dwell times (40). During the traversing, imaging data are acquired using the detector head. The acquired imaging data are reconstructed to generate a reconstructed image of at least the region of interest. A gamma camera (10) configured to perform the foregoing imaging method is also disclosed.