Invention Grant
US08192741B2 Method of treating rheumatoid arthritis with an anti-IL-6R antibody
有权
用抗IL-6R抗体治疗类风湿性关节炎的方法
- Patent Title: Method of treating rheumatoid arthritis with an anti-IL-6R antibody
- Patent Title (中): 用抗IL-6R抗体治疗类风湿性关节炎的方法
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Application No.: US13286261Application Date: 2011-11-01
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Publication No.: US08192741B2Publication Date: 2012-06-05
- Inventor: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
- Applicant: Allen Radin , Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Izumi Yokoyama
- Agent Frank R. Cottingham; Valeta Gregg
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.
Public/Granted literature
- US20120045440A1 METHOD OF TREATING RHEUMATOID ARTHRITIS WITH AN ANTI-IL-6R ANTIBODY Public/Granted day:2012-02-23
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