Invention Grant
- Patent Title: Genetically encoded fluorescent coumarin amino acids
- Patent Title (中): 遗传编码荧光香豆素氨基酸
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Application No.: US12227383Application Date: 2007-05-21
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Publication No.: US08192952B2Publication Date: 2012-06-05
- Inventor: Jiangyun Wang , Jianming Xie , Peter G. Schultz
- Applicant: Jiangyun Wang , Jianming Xie , Peter G. Schultz
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Quine Intellectual Property Law Group, P.C.
- International Application: PCT/US2007/012361 WO 20070521
- International Announcement: WO2007/139870 WO 20071206
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12N15/74 ; C12N1/21
Abstract:
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
Public/Granted literature
- US20090298119A1 Genetically encoded coumarin amino acids Public/Granted day:2009-12-03
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