Invention Grant
- Patent Title: Phenolic hydrazone macrophage migration inhibitory factor inhibitors
- Patent Title (中): 酚腙巨噬细胞迁移抑制因子抑制剂
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Application No.: US12225572Application Date: 2007-03-23
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Publication No.: US08193247B2Publication Date: 2012-06-05
- Inventor: Yousef Al-Abed
- Applicant: Yousef Al-Abed
- Applicant Address: US NY Manhasset
- Assignee: The Feinstein Institute for Medical Research
- Current Assignee: The Feinstein Institute for Medical Research
- Current Assignee Address: US NY Manhasset
- Agency: Amster Rothstein & Ebenstein LLP
- International Application: PCT/US2007/007277 WO 20070323
- International Announcement: WO2007/112015 WO 20071004
- Main IPC: A61K31/13
- IPC: A61K31/13 ; C07C249/00 ; A61P29/00
Abstract:
Provided are various compounds of Formula (I): Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.
Public/Granted literature
- US20090170951A1 Phenolic Hydrazone Macrophage Migration Inhibitory Factor Inhibitors Public/Granted day:2009-07-02
Information query
