发明授权
US08202520B2 Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
有权
使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法
- 专利标题： Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine
- 专利标题（中）： 使用Vi-rEPA结合疫苗免疫人类伤寒沙门氏菌的方法
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申请号： US12790258申请日： 2010-05-28
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公开(公告)号： US08202520B2公开(公告)日： 2012-06-19
- 发明人: Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins , Rachel Schneerson , Joseph Shiloach
- 申请人： Zuzana Kossaczka , Shousun Chen Szu , John B. Robbins , Rachel Schneerson , Joseph Shiloach
- 申请人地址： US DC Washington
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： A61K39/385
- IPC分类号： A61K39/385
摘要：
This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies against S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
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