发明授权
US08202887B2 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
有权
2-（取代 - 氨基） - 苯并噻唑磺酰胺HIV蛋白酶抑制剂
- 专利标题： 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
- 专利标题（中）： 2-（取代 - 氨基） - 苯并噻唑磺酰胺HIV蛋白酶抑制剂
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申请号： US12304990申请日： 2007-06-22
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公开(公告)号： US08202887B2公开(公告)日： 2012-06-19
- 发明人: Herman De Kock , Tim Hugo Maria Jonckers , Paul Jozef Gabriel Maria Boonants , Stefaan Julien Last , Inge Dierynck , Judith Eva Baumeister , Gerben Albert Van 'T Klooster
- 申请人： Herman De Kock , Tim Hugo Maria Jonckers , Paul Jozef Gabriel Maria Boonants , Stefaan Julien Last , Inge Dierynck , Judith Eva Baumeister , Gerben Albert Van 'T Klooster
- 申请人地址： IE Little Island
- 专利权人： Janssen R&D Ireland
- 当前专利权人： Janssen R&D Ireland
- 当前专利权人地址： IE Little Island
- 优先权： EP06116003 20060623
- 国际申请： PCT/EP2007/056235 WO 20070622
- 国际公布： WO2007/147884 WO 20071227
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/425 ; C07D277/82 ; C07D277/60 ; C07D261/20
摘要：
The present invention relates to 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present 2-(substituted-amino)-benzothiazole sulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.
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