Invention Grant
US08202891B2 Quaternary ammonium compounds useful as muscarinic receptor antagonists
有权
可用作毒蕈碱受体拮抗剂的季铵化合物
- Patent Title: Quaternary ammonium compounds useful as muscarinic receptor antagonists
- Patent Title (中): 可用作毒蕈碱受体拮抗剂的季铵化合物
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Application No.: US12148887Application Date: 2008-04-23
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Publication No.: US08202891B2Publication Date: 2012-06-19
- Inventor: Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
- Applicant: Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/4468
- IPC: A61K31/4468 ; C07D211/58
Abstract:
The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.
Public/Granted literature
- US20080269190A1 Quaternary ammonium compounds useful as muscarinic receptor antagonists Public/Granted day:2008-10-30
Information query
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