A multi-scale method to efficiently determine the fine-scale saturation arising from multi-phase flow in a subsurface reservoir is disclosed. The method includes providing a simulation model that includes a fine-scale grid defining a plurality of fine-scale cells, and a coarse-scale grid defining a plurality of coarse-scale cells that are aggregates of the fine-scale cells. The coarse-scale cells are partitioned into saturation regions responsive to velocity and/or saturation changes from the saturation front. A fine-scale saturation is determined for each region and the saturation regions are assembled to obtain a fine-scale saturation distribution. A visual display can be output responsive to the fine-scale saturation distribution.