The present invention is directed towards systems and methods for integrating cache managing and application firewall processing in a networked system. In various embodiments, an integrated cache/firewall system comprises an application firewall operating in conjunction with a cache managing system in operation on an intermediary device. In various embodiments, the application firewall processes a received HTTP response to a request by a networked entity serviced by the intermediary device. The application firewall generates metadata from the HTTP response and stores the metadata in cache with the HTTP response. When a subsequent request hits in the cache, the metadata is identified to a user session associated with the subsequent request. In various embodiments, the application firewall can modify a cache-control header of the received HTTP response, and can alter the cookie-setting header of the cached HTTP response. The system and methods can significantly reduce processing time associated with application firewall processing of web content exchanged over a network.