- 专利标题: Solvent/polymer solutions as suspension vehicles
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申请号: US13158137申请日: 2011-06-10
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公开(公告)号: US08206745B2公开(公告)日: 2012-06-26
- 发明人: Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
- 申请人: Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
- 申请人地址: US CA Hayward
- 专利权人: Intarcia Therapeutics, Inc.
- 当前专利权人: Intarcia Therapeutics, Inc.
- 当前专利权人地址: US CA Hayward
- 代理商 Gary R. Fabian; Barbara G. McClung
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K45/00 ; A61K38/47 ; A61K38/00
摘要:
A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
公开/授权文献
- US20110264077A1 SOLVENT/POLYMER SOLUTIONS AS SUSPENSION VEHICLES 公开/授权日:2011-10-27
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