发明授权
- 专利标题: Fused pyrimidines as reverse transcriptase inhibitors
- 专利标题(中): 融合嘧啶作为逆转录酶抑制剂
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申请号: US12334371申请日: 2008-12-12
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公开(公告)号: US08207178B2公开(公告)日: 2012-06-26
- 发明人: Alex Shaginian , Samedy Ouk , Jean-Michel Vernier , Anthony B. Pinkerton
- 申请人: Alex Shaginian , Samedy Ouk , Jean-Michel Vernier , Anthony B. Pinkerton
- 申请人地址: US CA San Diego
- 专利权人: Ardea Biosciences, Inc.
- 当前专利权人: Ardea Biosciences, Inc.
- 当前专利权人地址: US CA San Diego
- 代理机构: Wilson, Sonsini, Goodrich & Rosati
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/519 ; A61P31/18 ; C07D473/30 ; A61K31/52
摘要:
Described herein are novel enzyme inhibitors. In some embodiments, the enzyme inhibitors are reverse transcriptase inhibitors, particularly HIV reverse transcriptase inhibitors. Also described herein are compositions containing them and methods of using them. Thus, the compounds and compositions described herein are useful for the in vitro and in vivo inhibition of HIV reverse transcriptase as a method of treating or preventing HIV, AIDS or related disorders. In some embodiments, the enzyme inhibitors are compounds of formula (I) or a pharmaceutically acceptable salt or tautomer thereof:
公开/授权文献
- US20090162319A1 REVERSE TRANSCRIPTASE INHIBITORS 公开/授权日:2009-06-25