发明授权
US08207315B2 Gene and protein associated with angiogenesis and endothelial cell-specific apoptosis
有权
与血管生成和内皮细胞特异性凋亡相关的基因和蛋白质
- 专利标题： Gene and protein associated with angiogenesis and endothelial cell-specific apoptosis
- 专利标题（中）： 与血管生成和内皮细胞特异性凋亡相关的基因和蛋白质
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申请号： US10569744申请日： 2004-08-20
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公开(公告)号： US08207315B2公开(公告)日： 2012-06-26
- 发明人: Qing K. Wang , Xiao-Li Tian , Rajkumar Kadaba
- 申请人： Qing K. Wang , Xiao-Li Tian , Rajkumar Kadaba
- 申请人地址： US OH Cleveland
- 专利权人： The Cleveland Clinic Foundation
- 当前专利权人： The Cleveland Clinic Foundation
- 当前专利权人地址： US OH Cleveland
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 国际申请： PCT/US2004/027324 WO 20040820
- 国际公布： WO2005/019432 WO 20050303
- 主分类号： C07H21/02
- IPC分类号： C07H21/02
摘要：
This invention provides isolated nucleic acid and amino acid sequences encoding VG5Q, a novel angiogenic growth factor protein with pro-angiogenic activity, a forkhead-associated domain, a G-patch domain; characteristic subcellular localization in an in vitro Matrigel model of angiogenesis: towards the cell periphery in early stages of tubulogenesis, between cells in newly formed endothelial tubes, and no nuclear staining after 24 hours; is expressed in endothelial cells; is secreted during angiogenesis; and interacts with TWEAK. The invention also provides for expression vectors containing nucleic acid sequences encoding VG5Q protein, and host cells containing one or more expression vectors for the recombinant expression of VG5Q. The invention also provides for methods of using VG5Q for the diagnosis and treatment of angiogenesis-mediated diseases or disorders.
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