发明授权
US08211467B2 Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles
有权
渗透性药物递送装置含有包含具有活性剂和非水性单相载体的颗粒的悬浮液制剂
- 专利标题: Osmotic drug delivery devices containing suspension formulations comprising particles having active agents and nonaqueous single-phase vehicles
- 专利标题(中): 渗透性药物递送装置含有包含具有活性剂和非水性单相载体的颗粒的悬浮液制剂
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申请号: US12925864申请日: 2010-11-01
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公开(公告)号: US08211467B2公开(公告)日: 2012-07-03
- 发明人: Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
- 申请人: Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
- 申请人地址: US CA Hayward
- 专利权人: Intarcia Therapeutics, Inc.
- 当前专利权人: Intarcia Therapeutics, Inc.
- 当前专利权人地址: US CA Hayward
- 代理商 Gary R. Fabian; Barbara G. McClung
- 主分类号: A61K9/24
- IPC分类号: A61K9/24 ; A61K9/14 ; A61K38/47 ; A61K47/00 ; A61K47/30 ; A61K47/32 ; A61K47/34 ; A61F2/00
摘要:
A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
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