发明授权
US08211904B2 Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
有权
用于治疗阿尔茨海默氏病的Spiropiperidineβ-分泌酶抑制剂
- 专利标题： Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
- 专利标题（中）： 用于治疗阿尔茨海默氏病的Spiropiperidineβ-分泌酶抑制剂
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申请号： US11487229申请日： 2006-07-14
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公开(公告)号： US08211904B2公开(公告)日： 2012-07-03
- 发明人: Craig A. Coburn , Melissa S. Egbertson , Samuel L. Graham , Georgia B. McGaughey , Shaun R. Stauffer , Hemaka A. Rajapakse , Philippe G. Nantermet , Shawn J. Stachel , Wenjin Yang , Wanli Lu , Bruce Fahr
- 申请人： Craig A. Coburn , Melissa S. Egbertson , Samuel L. Graham , Georgia B. McGaughey , Shaun R. Stauffer , Hemaka A. Rajapakse , Philippe G. Nantermet , Shawn J. Stachel , Wenjin Yang , Wanli Lu , Bruce Fahr
- 申请人地址： US NJ Rahway US CA South San Francisco
- 专利权人： Merck, Sharp & Dohme Corp.,Sunesis Pharmaceuticals, Inc.
- 当前专利权人： Merck, Sharp & Dohme Corp.,Sunesis Pharmaceuticals, Inc.
- 当前专利权人地址： US NJ Rahway US CA South San Francisco
- 代理商 Keith D. MacMillan; Gerard M. Devlin
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D401/04 ; C07D403/04
摘要：
The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.