发明授权
US08212045B2 Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
有权
吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物作为葡萄糖激酶激活剂用于治疗糖尿病
- 专利标题： Pyridin-2-yl-amino-1, 2, 4-thiadiazole derivatives as glucokinase activators for the treatment of diabetes mellitus
- 专利标题（中）： 吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物作为葡萄糖激酶激活剂用于治疗糖尿病
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申请号： US12678995申请日： 2008-09-15
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公开(公告)号： US08212045B2公开(公告)日： 2012-07-03
- 发明人: Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
- 申请人： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
- 申请人地址： US CO Boulder
- 专利权人： Array BioPharma, Inc.
- 当前专利权人： Array BioPharma, Inc.
- 当前专利权人地址： US CO Boulder
- 代理机构： Banner & Witcoff, Ltd.
- 国际申请： PCT/US2008/076401 WO 20080915
- 国际公布： WO2009/042435 WO 20090402
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D417/00
摘要：
Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.
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