A Bluetooth host in a normal mode is enabled to monitor activities at USB endpoints. A Bluetooth USB radio has one or more active Bluetooth connections with peer Bluetooth radios. When each of the Bluetooth connections is in sniff mode, the Bluetooth host enables cancellation of normal USB activities at USB endpoints to enter a low power mode. The Bluetooth connections are still alive while the Bluetooth host is in the low power mode. In the low power mode, the Bluetooth host is enabled not to poll the bulk endpoint and to poll a USB interrupt endpoint in extended intervals for Bluetooth data received from the Bluetooth USB radio. The Bluetooth host is enabled to switch from the low power mode to the normal mode to process the received Bluetooth data over the bulk endpoint when a specific HCI event is received over the interrupt endpoint.