Invention Grant
US08217052B2 Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof 有权
取代的四氢吡喃螺吡咯烷酮和哌啶酮,其制备和治疗用途

Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
Abstract:
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.
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