Invention Grant
- Patent Title: Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
- Patent Title (中): 取代的四氢吡喃螺吡咯烷酮和哌啶酮,其制备和治疗用途
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Application No.: US13151925Application Date: 2011-06-02
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Publication No.: US08217052B2Publication Date: 2012-07-10
- Inventor: Zhongli Gao , Ryan Hartung , David Stefany
- Applicant: Zhongli Gao , Ryan Hartung , David Stefany
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Kelly L. Bender
- Priority: FR0955909 20090828
- Main IPC: A61K31/438
- IPC: A61K31/438 ; A61K31/454 ; A61K31/4545 ; A61K31/407 ; C07D491/107 ; C07D401/04 ; C07D401/14 ; C07D401/02

Abstract:
The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.
Public/Granted literature
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