A system and method are provided for monitoring bladder distention. Independently controllable acoustic transmitters are coupled to the surface of a user's abdomen region in a spaced-apart fashion. Each transmitter can introduce a broadband acoustic signal into a portion of the abdomen region. Acoustic receivers are also coupled to the surface of the abdomen region to detect acoustic reflections generated when the acoustic signals are introduced into the abdomen region. A controller is positioned on the user and is correlated to an orientation of the user. The controller stores a profile indicative of anatomical features of the user. The controller initiates periodic activations of selected ones of the transmitters based upon the profile and the orientation of the user. The controller uses a weighted combination of all of the acoustic reflections to determine bladder distention of the user. The weighted combination is defined by at least the profile and orientation of the user.